mdcalc.com | SIRS, Sepsis, and Septic Shock Criteria

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Units: US SI

SIRS, Sepsis, and Septic Shock Criteria

Check with your own hospital for its sepsis guidelines, sepsis "bundle" or sepsis algorithm. Two excellent references (PDF) come from the EMCrit website.

Posted in: Critical Care • Immunology • Infectious Disease

SIRS Criteria (≥ 2 meets SIRS definition)
Temp >38°C (100.4°F) or < 36°C (96.8°F)?	Yes
Heart Rate > 90?	Yes
Respiratory Rate > 20 or PaCO₂ < 32 mm Hg	Yes
WBC > 12,000/mm>³, < 4,000/mm>³, or > 10% bands?	Yes
Sepsis Criteria (SIRS + Source of Infection)
Suspected or Present Source of Infection?	Yes
Severe Sepsis Criteria
Organ Dysfunction, Hypotension, or Hypoperfusion? Lactic Acidosis, SBP <90 or SBP Drop >40 mm Hg of normal, etc	Yes
Septic Shock Criteria
Severe Sepsis with Hypotension, despite adequate fluid resuscitation?	Yes
Multiple Organ Dysfunction Syndrome Criteria
Evidence of ≥ 2 Organs Failing?	Yes

SIRS, Sepsis, and Septic Shock Criteria

Equations

Scores