SLICC Criteria for Systemic Lupus Erythematosus (SLE) 2012

Lupus malar rash (not malar discoid), bullous lupus, toxic epidermal necrolysis variant of SLE, maculopapular lupus rash, photosensitive lupus rash (not dermatomyositis), subacute cutaneous lupus (nonindurated psoriasiform and/or annular polycyclic lesions that resolve without scarring, although occasionally with postinflammatory dyspigmentation or telangiectasias)

Localized (above the neck) and/or generalized (above and below the neck) classical discoid rash, hypertrophic (verrucous) lupus, lupus panniculitis (profundus), mucosal lupus, lupus erythematosus tumidus, chilblains lupus, discoid lupus/lichen planus overlap

Palate, buccal, tongue, or nasal ulcers; in absence of other causes

In absence of other causes

Involving ≥2 joints, characterized by swelling or effusion OR tenderness in ≥2 joints and 30 mins or more of morning stiffness

Typical pleurisy for >1 day, pleural effusions, or pleural rub, typical pericardial pain for >1 day, pericardial effusion, pericardial rub, or pericarditis by EKG (in absence of other causes)

Urine protein/creatinine (or 24 hr urine protein) representing 500 mg of protein/24 hr, RBC casts

Seizures, psychosis, mononeuritis multiplex (in absence of other causes), myelitis, peripheral or cranial neuropathy (in absence of other causes), acute confusional state (in absence of other causes)

In absence of other causes

<4,000/mm³ at least once (leukopenia) or <1,000/mm³ at least once (lymphopenia); in absence of other causes

<100,000/mm³ at least once; in absence of other causes

Lupus anticoagulant, false positive RPR, medium or high titer anticardiolipin (IgA, IgG, or IgM), anti-β₂ glycoprotein (IgA, IgG, or IgM)

Low C3, low C4, low CH50

In the absence of hemolytic anemia