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    International Working Group (IWG) 2 Criteria for Alzheimer's Disease Diagnosis

    Diagnoses Alzheimer disease (AD), newer than NINCDS-ADRDA Criteria.

    Exclusion criteria for typical AD: history
    (if any are present, diagnosis is not typical AD)
    Exclusion criteria for typical AD: clinical features
    (if any are present, diagnosis is not typical AD)
    Exclusion criteria for typical AD: other medical conditions
    (if any are present, diagnosis is not typical AD)
    Specific clinical phenotype (must have both)
    Early significant episodic memory impairment (isolated or associated with cognitive/behavioral changes suggesting mild cognitive impairment or dementia syndrome) that includes both of the following:
    In-vivo evidence (must have ≥1)

    Diagnostic Result

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    Microscope IconDiagnosis
    NINCDS-ADRDA Criteria for Alzheimer’s

    NINCDS-ADRDA Criteria for Alzheimer’s

    Microscope IconDiagnosis
    Clinical Dementia Rating (CDR) Scale

    Clinical Dementia Rating (CDR) Scale

    Microscope IconDiagnosis
    Montreal Cognitive Assessment (MoCA)

    Montreal Cognitive Assessment (MoCA)

    Dr. Bruno Dubois
    Dr. Bruno Dubois
    About the creator
    Bruno Dubois, MD, PhD, is a professor of neurology at University Pierre and Marie Curie in Paris, France. He is also the director of the Institute for Memory and Alzheimer’s Disease at the Pitié-Salpêtrière Hospital in Paris, France. Dr. Dubois’ primary research is focused on Alzheimer’s disease, prodromal Alzheimer’s disease, and Parkinson’s disease dementia.
    To view Dr. Bruno Dubois's publications, visit PubMed
    Are you Dr. Bruno Dubois? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
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