DigiFab (Digibind) Dosing for Digoxin Poisoning
Doses DigiFab in patients with confirmed digoxin poisoning or overdose.
This dosing tool is intended to assist with calculation, not to provide comprehensive or definitive drug information. Always double-check dosing of any drug and consult a pharmacist when necessary.
Therapeutic range for serum digoxin level is 0.8–2.0 ng/mL (1.0–2.6 nmol/L). If acute poisoning and serum digoxin confirmed >10 ng/mL, give empiric dose (10-20 vials). See Evidence for details.
Additional considerations for treatment of digoxin toxicity include:
- Atropine 0.5 mg IV for acute toxicity if bradydysrhythmias or high degree AV block.
- Cautious correction of electrolyte abnormalities, specifically hypokalemia and hypomagnesemia (may result in dysrhythmias at lower serum digoxin levels).
Result:
Frédéric Lapostolle, MD, PhD, is an emergency physician at Avicenne Hospital in Bobigny, France. He is deputy medical director of Samu 93 Emergency Rescue Service. Dr. Lapostolle is a professor of emergency medicine and has authored or co-authored over 100 papers in his specialty.
- Scott Lucyk, MD
