Phenytoin (Dilantin) Correction for Albumin/Renal Failure
Corrects serum phenytoin level for renal failure and/or hypoalbuminemia.
Use in patients with albumin ≤3.2 g/dL (32 g/L). The “Sheiner-Tozer Equation” is the official name of this correction. This updated formula uses an albumin coefficient of 0.275, and 0.2 for patients with renal failure (see Evidence for details).
Result:
Thomas N. Tozer, PhD, PharmD, BS, is professor emeritus of biopharmaceutical sciences and pharmaceutical chemistry at School of Pharmacy at UCSF. He is the co-author of Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications. Prior to retirement, Dr. Tozer researched colon-specific drug delivery, toxicokinetics, kinetics of potential contrast agents for magnetic resonance imaging and nonlinear pharmacokinetics.
- Andrew Michalak, MD